Hyperalgesia [...]

The potential side effects of prescription narcotics include constipation, sexual dysfunction, cognitive impairment, addiction, and overdosing. When patients receive narcotics for long periods, they can even become more sensitive to pain, a condition called hyperalgesia. (J. David Haddox, the vice-president of health policy at Purdue Pharma—the manufacturer of OxyContin—acknowledged “opioid analgesics have sometimes been associated with diminished pain relief in the face of increasing doses.”) (Source)

Hyperalgesia was dismissed as a concern in an influential study. See Perils of a Small Study, Opioid Edition

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